The Potential And Its Effects On Cancer Cells - 1535 Words

Limitless replicative potential is an acquired capability of many cancer cells, and it was listed as one of the original hallmarks of cancer [1]. It is mostly achieved by upregulation of telomerase, a reverse transcriptase DNA synthesis enzyme that maintains the telomeres length. Most tumor cells have a high level of telomerase activity but short telomeres due to prior divisions before achieving telomerase-activating malignancies [2]. In contrast, normal progenitor cells and stem cells have relatively long telomeres and lower mitotic/telomerase activity, and in normal differentiated somatic cells telomerase expression is repressed. Thus, telomerase inhibition provides an attractive therapeutic opportunity because of its universality, criticality and specificity for cancer cells [3]. Numerous strategies have been proposed for silencing this enzyme [reviewed in 2-3], but due to heterogeneity and complexity of cancers, as well as polymorphisms in human genomes, the search for effective and precise treatments for polymerase inhibition is still active. Nanotechnology is the latest evolving field, and its applications in cancer therapeutics have demonstrated great potential. Specifically, nanomedicine utilizes the advantages of nanodelivery systems [4]. The nanocarrier system is a new system for transporting biological molecules that has the advantages of being highly efficient, non-immunogenic, safe, inexpensive, biodegradable, and stable [4]. As a result, some previouslyShow MoreRelatedIs Cancer A Serious Health Condition?869 Words   |  4 PagesAccording to the American Cancer Society (2015a), a total of 589, 430 citizens of the United States are expected to die from cancer this year. In the United States, it is identified as the second most common cause of death next to heart disease. With these facts, there is no doubt that cancer is a serious health condition that many people face today. The term cancer is defined as a â€Å"group of diseases characterized by the uncontrolled growth and spread of abnormal cells† (American Cancer Society, 2015a). ARead MoreIs Cancer A Serious Health Condition? Essay856 Words   |  4 PagesIntroduction According to the American Cancer Society (2015a), a total of 589, 430 citizens of the United States are expected to die from cancer this year. In the United States, it is identified as the second most common cause of death next to heart disease. The term cancer is defined as a â€Å"group of diseases characterized by the uncontrolled growth and spread of abnormal cells† (American Cancer Society, 2015a). A person dies from cancer once the spread of these abnormal cells is not controlled. 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When MCF-7 and HepG2 cell lines treated with 5-ALA (0.5, 1, 1.5 and 2mM) alone for 4h then incubated for 24h, 5-ALA did not induce cytotoxic effects on both cell lines. Also, laser irradiation alone did not induce a cytotoxic effect on MCF-7 orRead MoreCance r And Its Effects On Cancer Essay1504 Words   |  7 Pagespeople in the world suffer from cancer. In the year 2017, it is estimated that nearly 2 million new cancer cases will occur in the United States, leading to approximately more than half a million deaths (Cancer Facts Figures, 2016, p.1). However, despite the drastic numbers shown in this data, it is almost a 20% decrease from data collected in previous years (Tao Kiera, 2015, p.1). The increased survival rate of cancer patients is mainly due to advances in cancer research and the incorporationRead MoreHuman Neural Stem Cell Tropism857 Words   |  4 PagesARTICLE TITLE: Human Neural Stem Cell Tropism to Metastatic Breast Cancer ESSAY TITLE: The Investigation of a therapeutic implication on metastatic breast cancer with a specialized human neural stem cell that is programed to secrete carboxylesterase combined with activated form of an ionotecan by targeting a specific tumor site and major cytokine involved in mediating susceptibility of neural stem cells to breast cancer cells. SCIENTIFIC SUMMARY: Metastatic Breast Cancer is characterized as a severe